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AB BIODISK, SWEDEN - The AB BIODISK name, company spirit and reputation are based on commitment to the highest standards of science. The company is perhaps best known for its dedication to antimicrobial resistance testing since the early 1950s. The mission left by its scientific founder, Hans Ericsson, Professor of Microbiology at the Karolinska Institute, Promote the Rational Use of Antibiotics has been faithfully pursued for over 50 years. AB BIODISK develops new product concepts and processes for manufacturing unique high quality diagnostic tests. The company's proprietary technology enables biochemical reagents to be accurately dispensed in picogram quantities in stable dry-chemistry formats. This innovative technique is used to produce antibiotic gradients for products like Etest®, System U3®, BIOTOOLS™ and other forthcoming products. Significant resources are dedicated to research and development and include in vitro studies of new antibiotics, antifungal and antimycobacterial agents. Susceptibility testing of fastidious and unusual organisms, detection of resistance mechanisms and epidemiologic investigations often involve collaborative work with laboratories throughout the world. This research exchange has opened up new product applications for testing of anaerobes, H. pylori, M. tuberculosis, M. avium-intracellulare, yeasts, moulds, mycoplasma and many other challenging organisms. Studies of enzymes conferring resistance e.g. ESBLs, metallo beta-lactamases, AmpC and other resistance mechanisms such as glycopeptide resistance in staphylococci and enterococci are on-going projects.
Etest® is the first in a new generation of novel and patented products for Anti-microbial Resistance Testing. First presented at the Interscience Conference on Antimicrobial Agents and Chemo-therapy (ICAAC) in 1988, the Etest® trademark now enjoys international recognition as a significant innovation. Etest® comprises a predefined gradient of antibiotic concentrations on a plastic strip. It is used to determine the exact Minimum Inhibitory Concentration (MIC) of antibiotics, antifungal agents and antimycobacterial agents. Precise quantitative MIC data is now a prerequisite for management of critical infections, especially among critical care patients. Etest® is recognised as a cost-effective tool for generating MICs across 15 dilutions. It can also be used in a macromethod format to optimise resistance detection. Over 100 anti-biotics are now available in the product range for testing of aerobic bacteria and fastidious organisms like pneumococci, haemophilus, H. pylori, meningococci, gonococci, anaerobes, fungi and mycobacteria. Etest promotes the rational use of antibiotics by providing accurate results to guide the therapy of individual patients and to validate empiric drug regimens on a unit specific basis. It is also widely used in resistance surveillances and clinical trials. (Download product/price lists) Etest® is a registered trademark of AB BIODISK and patented in all major markets.
System U3® is a new patented product introduced at the ICAAC in 1997. It is a unique self Interpreting Reagent strip for accurate assessment of the antibiotic susceptibility categories of urinary tract pathogens. System U3® is also based on the predefined gradient technology underlying Etest®. The antibiotic gradient is designed such that MIC break points for Susceptible and Resistant categories are positioned on the strip to give the best discrimination between S, I and R results. The product can be used to test urine isolates or for direct testing of the urine specimen itself. Launch of System U3® is pending. System U3® is a registered trademark of AB BIODISK and patented in all major markets.
PDM® PDM® (Paper Disc Method) was the company's first product line introduced as early as 1958. It represents the earliest concept for antibiotic susceptibility testing using a single disc in a well standardised diffusion method. The PDM® concept integrates the use of a specially formulated susceptibility test medium, PDM® ASM, specifically calibrated PDM® Antibiotic Sensitivity Discs and a well defined test procedure to generate underlying PDM® interpretive criteria. All components are controlled strictly batch-to-batch to ensure the validity of interpretive standards. Additional products include PDM® Nitrocefin Disc for beta-lactamase detection and PDM® Standard Discs for antibiotic assays. PDM® products are marketed in the Scandinavian countries only. (Download product/price lists) PDM® is a registered trademark of AB BIODISK.
Simplex C76™ The key instrument in a new family of Biotools™ developed by AB BIODISK to simplify the use of Etest® for MIC determinations. The instrument can be used to automatically apply Etest® strips onto inoculated agar plates, both 90 mm and 150 mm, in predetermined patterns. Many strains can be rapidly set up with flexible MIC antibiograms, making a monotonous task efficient and easy. The instrument is very useful for daily clinical work and for surveillances involving high numbers of strains. Nema C88™ A vacuum pen that can be used to efficiently apply Etest® strips onto inoculated agar plates. Using templates placed underneath the plate, different MIC antibiograms can be quickly and accurately positioned onto the agar. This instrument is indispensable to the Etest® user. Retro C80™ An instrument that can be used to inoculate the agar surface to obtain an even lawn of growth. It simplifies the set up for use of Etest® and/or antibiotic discs. This ergonomic tool has a turntable plate holder that can rotate at varying speeds so that the inoculation process can be comfortably adjusted to user preference. Both 150 mm and 90 mm plates can be used. (Download product/price lists)
A family of new instruments comprising Simplex C76™, Nema C88™ and Retro C80™ are now available to simplify the use of Etest® for MIC determinations. Details under Products Etest® Cefepime Clavulanic acid for Detection of ESBL (PM/PML) Etest® PM/PML is an additional tool for detection of ESBL among Entero-bacteriaceae, Gram negative non-fermenters and for further investigation of non-determinable results with current methods. Etest® ESBL (PM/PML), Art. No. 5100 3478. In the USA, For Investigational Use Only. Etest® MBL for Metallo Beta-Lactamases Etest® MBL uses imipenem (IP) and imipenem + EDTA (IPI) to detect metallo beta-lactamases in Gram negative aerobes and anaerobes. Etest® MBL (IP/IPI), Art. No. 5100 3428. In the USA, For Investigational Use Only. (Download product/price lists)
Commissioned Research Commissioned research involving in vitro studies of new antimicrobial agents is provided for the pharmaceutical industry. This may involve a variety of projects: - Development of PDM Antibiotic
Sensitivity Discs for new compounds Etest® and System U3® is a registered trademark of AB BIODISK and patented in all major markets. AB BIODISK is a privately held company with facilities for research and development, manufacturing and marketing situated in Solna, Sweden.
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